The study entitled “Studies on Effect of Integrated Nutrient Management on Yield, Quality, Disease resistance and Plant Nutrition of Pomegranate (Punica granatum L.) Orchard” was conducted during the year 2017-18 and 2018-19 at research farm, College of Agriculture, Golegaon, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani. Five years old, fifty six pomegranate trees having uniform growth and vigor were selected for experiment. The experiment was laid out in Randomized Block Design (RBD) with seven treatments replicated four times. The treatment consist of T1- Absolute Control, T2- Farmer’s Practices (½ RDF), T3- RDF (625:250:250 g N, P2O5, K2O tree-1), T4- INM (15 kg FYM + 8 ml Azotobactor, 8 ml PSB, 100 g Trichoderma + RDF), T5- RDF + Antibiotics (Streptocycline @ 250 ppm per tree), T6- T4 + Antibiotics and T7- T4 + Umber (Ficus racemosa) Rhizosphere Hybridised Soil (URHS @ 25 kg per tree). Result showed that yield attributes viz., number of flower, number of fruits, fruit set, fruit weight and yield of pomegranate were significantly increased, disease severity of leaf, fruit and twig reduced, quality parameters of pomegranate in respect of total soluble sugar, titrable acidity and colour of juice improved with application of RDF, nutrient solubilizers, organic manures and Umber (Ficus racemosa) Rhizosphere Hybridised Soil. The highest leaf N, P, K, Fe, Zn, Cu, Mn and B concentration were recorded with application 15 kg FYM tree-1, Azotobacter @ 8 ml per tree, PSB @ 8 ml per tree and Trichoderma @ 100 g per tree, 625:250:250 g N, P2O5 and K2O per tree and 25 kg URHS per tree (T7) at flowering and harvesting stage. Highest fruit nutrient content of pomegranate like N, P, K, Fe, Cu, Zn, Mn and B were also recorded with the same treatment after harvest of pomegranate.