A field experiment was conducted during two consecutive winter (rabi) seasons of 2016-17 and 2017-18 at Sardar krushinagar Dantiwada Agricultural University, Sardar krushinagar, Gujarat, India to assess the impact of varieties and integrated nutrient management practices on yield and economics of wheat. The treatments consisted of four wheat varieties viz. GW 273, GW 322, GW 451 and GW 496 and six integrated nutrient management practices viz. control, 100% RDF, 100% RDF + Azotobacter + PSB, 75% RDF + Azotobacter + PSB, 75% RDF + Azotobacter + PSB + ZnSO4 and 50% RDF + 25% N through FYM + Azotobacter + PSB + ZnSO4. Results indicated that maximum values of growth and yield parameters were recorded in variety GW 451 which was at par with GW 496. This variety proved as best in realizing the highest grain yield (4.99 t ha-1), net returns (₹ 68173 ha1 and benefit cost ratio (2.0). Among nutrient management practices, application of100% RDF (120 kg N and 60 kg P2O5 per ha) + Azotobacter + PSB significantly improved growth and yield attributes and produced 37.1 and 24.8% higher grain and straw yields over control, respectively. The highest economic returns and B:C ratio were also computed in this treatment. Therefore, wheat variety GW 451 fertilized with 100% RDF + Azotobacter + PSB can be suggested for higher grain and straw productivity and profitability.