A present experiment was conducted during the kharif season 2019 at the Research Farm, JNKVV, Jabalpur (M.P.) to study the efficacy of herbicidal mixtures against weed flora in direct-seeded rice under rainfed and irrigated agroecosystems. The experiment was laid out in a split-plot design with rainfed and irrigated agroecosystems in main plot treatments and eight weed control herbicides in sub-plot treatments. Among all kinds of dicot as well as monocot weeds Echinochloa colona and Alternanthera sessilis were the most dominant with a mean relative density of (30 and 28.6%) and (26 and 25%) respectively, under rainfed and irrigated agroecosystems. The maximum weed control efficiency under both rainfed and irrigated rice was observed in plots receiving hand weeding which was closely followed by bispyribac sodium at 25 g a.i./ha. Growth parameters, yield attributes as well as grain yield of direct-seeded rice were higher in plots receiving bispyribac sodium 10% SC at 25 g a.i./ha at 20 DAS except for hand weeding twice which registered the maximum values of these parameters.