Identification of appropriate method of mechanical weed control and inter-culture suitable crop row spacing are the important researchable areas in pearl millet agronomy. Considering this research gap, field experiment entitled “Weed dynamics, crop productivity and profitability of pearl millet as influenced by mechanized weed control under semi-arid agro-ecology of India” was undertaken with the aim of finding out the effect of experimentation on weed dynamics (weed flora distribution, weed density, weed control efficiency and weed index), crop productivity and profitability parameters (gross returns, cost of cultivation, net returns and benefit: cost (B:C) of pearl millet. The field experiment was carried out in Kharif, 2017 at Regional Research Station, Bawal, Rewari of Chaudhary Charan Singh Haryana Agriculture University (CCSHAU), Hisar. A combination of twelve treatments (manual weeding by kasola and wheel hand hoe however; mechanized weeding by tractor and power weeder) were allocated in randomized block design and replicated thrice. Dominant weed flora in the study were Cyperus rotundus, Trianthema portulacastrum, Digera arvensis whose relative weed density was 42% & 46%, 26% & 22% and 17% & 15% at 20 days after sowing (DAS) and at maturity stage, respectively. Treatment T8 (sowing at 60 cm row spacing and two inter-culture with power weeder) has resulted in lowest weed density and weed dry matter at 20 DAS while, T1 (sowing at 45 cm row spacing and two interculture with kasola) has resulted in lowest weed density, weed dry matter (2.66 & 3.41 g/m2) and weed control efficiency (92.5 & 89.1%) at 40 DAS and at maturity respectively T1 also resulted in lowest weed index (3.09%), higher crop productivity (29.43, 68.50 and 97.93 q/ha of grain, stover and biological yield, respectively) and high value of cost of cultivation and gross returns. However, T7 (sowing at 60 cm row spacing and two interculture with tractor) noted with at par productivity but higher net returns (Rs/ha, 23777.7) and higher B: C ratio (1.80) than T1.