Ethnoveterinary medicines play a significant role in traditional dairy farming practices. Ethnoveterinary medicines are often used by traditional dairy farmers to manage various aspects of animal health. There is every possibility of extinction of traditional knowledge in rural areas. Hence it is the need of the hour to document the prevailing traditional knowledge of various ailments of cattle. One such ailment is retained placenta. A survey was conducted with 40 representative farmers who were practicing ethno veterinary medicines to treat retained placenta were selected purposefully from 4 districts of Tamil Nadu in India to validate the different ethnoveterinary medicines used to treat retained placenta in cattle and also comparing the present ITKs with the Modern Veterinary drugs for treatment of retained placenta in cattle. A sample of 40 farmers were interviewed through structured interview schedule to document the ITK’s used for treatment of retained placenta. The six ITKs for the retained placenta condition were subjected to validation test through the QuIK (Quantification of Indigenous Technical Knowledge) method. All the ITKs were found to be effective against retained placenta. However, these were perceived to be comparatively less effective than the Modern Veterinary Drug (MVD) in numbers of animals cured and quickness of healing. The indigenous practices were perceived better than MVD in respect of their availability, lesser side effects and lower cost.