A biological trial was carried out with 216-day-old Vencobb 400 broiler chicks distributed to six experimental groups with six replicates, each replicate containing six chicks. The experimental groups were fed with control ration (T1), ration with antibiotic oxytetracycline (OTC) at 50 mg/kg (T2), ration with cinnamon oil (CO) at 250 mg per kg and coated sodium butyrate (CSB) either at 0.09 (T3) or 0.18 (T4) per cent levels and ration with CO at 500 mg per kg and CSB either at 0.09 (T5) or 0.18 (T6) per cent levels, lipid encapsulated sodium butyrate was used for the study. The trial was carried out in a deep litter pen for 35 days. The ileal Escherichia coli (5.52-5.71×105 vs. 6.85×106 cfu/g), total bacterial count (8.31-8.53×108 vs. 9.12×109 cfu/g) and Clostridium perfringens (3.90×103-4.23×104 vs. 5.00×105 cfu/g) count were reduced (P<0.01) on the addition of CO and CSB at either low or high levels of antibiotic while the Lactobacillus sp. count in ileal content was not influenced due to supplementation CO and CSB levels attempted or by the antibiotic. The jejunum villi height (1536.78 vs.1287.16 µm) was significantly (P<0.01) increased with the addition of CO and CSB at the levels tried or antibiotic but villi crypt depth and villi height: crypt depth ratio was not influenced by all CO and CSB levels or by the antibiotic. The inclusion of CO and CSB at different levels or antibiotics did not influence the Haemagglutination Inhibition titre against RD.