In the present investigation, an attempt has been made to study the effect of land use systems on soil physical, chemical and biological properties in eastern and south-eastern coastal plain zone of Odisha. We have employed Completely Randomized Design (CRD) technique over eight land use systems to analyze different soil properties of soil viz. MBC, MBN, SBP, SFP, SOC, BD, PD, EC, PH. It has been found from the analysis that the MBC, MBN, soil bacterial and fungal population is the higher in natural forest than other tree based land use systems. The bulk density, particle density, pH and EC of soils in different tree based land use systems are negatively correlated with microbial properties of soil but water holding capacity, soil organic carbon and available nitrogen is positively correlated with microbial properties of soil in different tree based land use systems. Among the tree based land use systems homestead agro forestry and teak plantation recorded physico-chemical and microbial properties comparable with natural forest and better than agricultural rice lands. It is found from the study that the land use homestead agro-forestry and teak plantation are recommended in the coastal area of Odisha for soil health improvement and sustainable production.