The present investigation on “Studies on the effect of organic manures, biofertilizers on growth, yield and quality of Turmeric (Curcuma longa L.) varieties” was conducted at College of Horticulture, Rajendranagar, SKLTSHU, Mulugu during 2019-20. The experiment was laid out in Factorial Randomized Block Design (FRBD) with 2 replications and 18 treatments. The results revealed that among all the organic manures, biofertilizers, varieties and their combinations, treatment M1 – FYM 45 t/ha + AMC (Arka microbial consortium) 1 lit per quintal manure recorded maximum antioxidant activity (12.01 µg mL-1), Curcumin content (5.75 %) and oleoresin content (9.25 %) followed by M3 – Vermicompost 14 t ha-1 + AMC (Arka microbial consortium) 1 l q-1 compost (12.53 µg mL-1), (5.46 %) and (8.22 %) respectively. Among the varieties, Salem recorded significantly the highest values for antioxidant activity (10.68 µg mL-1), curcumin content (6.03 %) and oleoresin content (10.20 %) followed by followed by V2 – First best treatment of first experiment (Vertical split of mother rhizome) of Rajendra Sonia variety (12.62 µg mL-1), (4.72 %) and (7.48 %) respectively. Among the interaction effects between organic manures, biofertilizers and varieties, the treatment M1V1 – FYM 45 t/ha + AMC (Arka microbial consortium) 1 lit per quintal manure + vertical split of mother rhizome of Salem variety recorded maximum antioxidant activity (10.18 µg mL-1) Curcumin content (7.14 %) and oleoresin content (12.38 %) followed by M3V1 – Vermicompost 14 t ha-1 + AMC (Arka microbial consortium) 1 l q-1 manure + First best variety of first experiment (Vertical split of mother rhizome) of Salem variety (10.51 µg mL-1), (6.41 %) and (10.69 %) respectively.