Potato crop encounters many foliar diseases like early blight caused by Alternaria alternata Fr. (Keissler) which drastically decrease tuber yield. Management of this disease remains as a challenge. The present studies were carried out at Nangarhar University Agriculture Faculty Research Farm in 2020 and at Bati kot in 2021. Ten different potato cultivars of Afghanistan were screened to recognize resistance level against early blight under artificial epiphytotic conditions. Parameters like temperature and relative humidity, disease incidence (DI), disease severity (DS), percent disease reduction, number of tubers per plant and tuber yield were recorded. Lowest DI was recorded in Sabzgul (16.53%) followed by Suria (22.45%) and Surkhgul (24.8%). Minimum DS was found in Surkhgul (46.90%) and Sabzgul (46.30%) that grouped in moderately susceptible category. The cultivars Surkhgul and Suria had similar average tuber numbers (7.00), but highest yield was obtained from Surkhgul (3.40 kg). The experiment on fungicidal cum biological management of early blight was conducted in 2020 at Behsood Farmers Learning and Research center (FLRC) of Behsood, Nangarhar, and at Bati kot in 2021. Out of eight treatments, maximum reduction of DI (47.84%) and DS (64.08%) was achieved by foliar spraying of fungicides Cymoxanil + Mancozeb. In addition, this fungicide contributed maximum tuber numbers (4.50) and highest yield (2.80 kg). It was followed by Azoxystrobin + Difenconazole (2.50 kg), and the bio-control with Trichoderma viride (2.40 kg) in terms of tuber yield. The study was the first of its kind carried out in Afghanistan.