Abiotic stress to plants is an important issue globally, particularly due to heavy metal pollutants, salinity, and drought. Many problems could be caused by these stresses, including the production of reactive oxygen species, membrane damage, loss of photosynthetic efficiency, etc. These problems could alter crop growth and development by affecting biochemical, physiological, and molecular processes, leading to a significant loss in productivity. Grapevines are no such exception. With this background, a study was conducted to evaluate the salinity tolerance of Thompson Seedless vines raised on Dogridge rootstock with varying levels of salinity viz., 0, 0.25, 0.5, 0.75, 1 and 2% NaCl. Salt stress resulted in reduced vegetative growth, chlorophyll and protein content whereas an increase in phenol and proline concentration was recorded due to stress-tolerance adaptive mechanisms. The concentration of sodium and chloride increased in vines whereas potassium concentration decreased. The concentration of sodium ranged from 0.14-0.69% in leaves, 0.09-0.28% in canes and 0.14-0.55% in roots and the chloride levels were 0.45-74, 0.26-60 and 0.43-1.21% in leaves, canes and roots respectively. However, the potassium content of vines grafted on Dogridge ranged from 1.20 to 0.78% in leaves, 0.97 to 0.30% in canes and 0.84 to 0.63% in roots. Elevated salt stress resulted in an increase in soil electrical conductivity, sodium and chloride concentration whereas reduced potassium content. The soil available nitrogen and phosphorus content also decreased due to reduced microbial diversity and microbiological activity essential for the process of nitrogen mineralization and precipitation of phosphorus with Ca2+ and Mg2+ cations. The tolerance index of Thompson Seedless grafted on Dogridge rootstock was recorded to be 102.36 (shoot/root dry weight basis). The use of tolerance ratios and tolerance indices can be an effective evaluation technique to test different rootstocks for salt tolerance.