Field experiment was conducted during rabi season to determine the “Response of foliar application of micronutrients and PGR on productivity and profitability of tomato (Solanum lycopersicum Mill.)” was carried out during 2018-19 and 2019-20 at Vegetable Research Farm of C. S. Azad University of Agriculture & Technology Kanpur U.P (208002) India. Experiment was laid out in a randomized block design (RBD) with eleven treatments replicated three times consist of two levels of each micronutrients and growth regulators with control i.e.T0: Control, T1: GA3 50ppm, T2: GA3 100ppm, T3: NAA 50ppm, T4: NAA 100ppm, T5: ZnSO4 0.5%, T6: ZnSO4 1%, T7: Boric acid 50ppm, T8: Boric acid 100ppm, T9: FeSO4 100ppm and T10: FeSO4 150ppm on Vegetable Crops. Azad-T6 variety of tomato was transplanted at a spacing of 60 cm × 45 cm. Results of the experiment revealed that the Application of GA3 100ppm concentration showed significantly increased growth, flowering, yield, fruit quality and economic return of tomato. Therefore, the concentration of PGR and micronutrients may be recommended to exploit the better eco-friendly economic yield of tomato.