Wheat is the one of the major cereal crop grown under subcontinent of India which faces deficit soil fertility and problem of weed infestation. Optimum fertilization and weed management plays an important role in yield enhancement of wheat in the arid region under loamy sand soil. In the present study, Chenopodium murale contributed the maximum population to total weeds followed by Chenopodium album before and after spray of herbicides. fertilization with 150-50 kg NP/ha showed significant increase in plant height and dry matter at 35 and 50 DAS stage over fertilization of 120-40 kg N-P/ha and 90-30 kg N-P/ha while remain at par with 120-40 kg N-P/ha fertilization in respect of plant height and dry matter at 75 DAS and harvest stage, grain yield straw yield and biological yield. Available nitrogen in soil after crop harvest significantly increase upto 120-40 kg N-P/ha, however available phosphorus increase up to 150-50 kg NP/ha. Among herbicidal weed management, clodinafop-propargyl 15% + metsulfuron-methyl 1% at 64 g/ha was found to be the most effective for better wheat growth (plant height and dry matter), higher yield (grain, straw and biological yield) and available soil nutrients (N and P) after harvest of crop.