A field experiment was conducted during kharif and rabi 2021-2022 at research farm of College of Post Graduate Studies in Agricultural Sciences, Umiam, Meghalaya with the objective of developing fertilizer adjustment equations and quantifying doses for achieving targeted yield of potato (Solanum tuberosum L.) by using soil test crop response (STCR) approach. At first, soil fertility gradient stabilizing experiment was conducted by which different fertility strips have been created and maize was grown. Based on yield difference and soil available nutrients, it has been proved that fertility gradient has been created with different levels of fertility which was being followed by a test crop experiment on potato. Response of potato to four levels of N, P, K and FYM under different fertility levels was studied. By using soil available nutrients, tuber yield and total nutrient uptake, basic parameters for development of equation have been calculated which are nutrient requirement (NR) were reported as 0.55, 0.26 and 0.93 kg q-1 for N, P and K, respectively, contribution of nutrients N, P, and K from fertilizers (% CF) was found as 33.32, 15.72 and 91.46 %, from soil (% CS) as 8.30, 46.21 and 17.74%, from organic matter FYM (% CFYM) as 11.33, 7.10 and 10.35%. Hence by following the prerequisites as mentioned above, the targeted yield equations can be developed.