Kalmegh (Andrographis paniculata) is an important medicinal crop indigenous to India and Sri Lanka that has been valued in ancient oriental and ayurvedic medicine for its immunopotenting ability against many diseases. All parts of the plant, such as leaves, roots, stems, etc., have value in the national and international markets, and any kind of damage due to diseases decreases value in terms of both quality and quantity. Kalmegh is susceptible to various diseases that reduce the yield and quality. Among different diseases, leaf spot disease caused by Corynespora cassiicola is an important disease of Kalmegh. Therefore, the present study was conducted to develop eco-friendly management strategies for Kalmegh leaf spot disease. With chemical fungicides having adverse effects on the environment and also on human health, new alternatives to disease management such as utilisation of plant parts or leaf extracts, introduction of biocontrol agents, exploration of native endophytes, as well as use of some eco-friendly fungicides to some extent for the commercial profit of the farmers. A total of six plant extracts, two bioagents, three fungal endophytes, and four bacterial endophytes isolated from the leaves and stem of the plant were evaluated against the three pathogens, and the results revealed that among the fungal bioagents, including Trichoderma asperellum and fungal endophytes, the highest inhibition against Corynespora cassiicola, Fusarium oxysporum, and Sclerotinia spp. was exhibited by the endophytic strain KLEPF-2 (49.50%), KLEPF-1 (55.13%) and Trichoderma asperellum (80.33%) respectively. In in vitro evaluation of the pathogens with bacterial endophytes and Pseudomonas fluorescens, the maximum inhibition against Corynespora cassiicola and Fusarium oxysporum was exhibited by Pseudomonas fluorescens by 80.89% and 75.47%, whereas the maximum inhibition was against Sclerotinia sclerotiorum shown by strain KLENB-1 (100%). Among the botanicals tested, Mugwort (Artemisia annua) was found to be most effective in inhibition of all three test pathogens at both 5% and 10% concentrations. Mugwort inhibited 100% mycelial growth in Sclerotinia sclerotiorum. In the course of the study on integrated management of Corynespora leaf spot in Kalmegh under pot conditions, application of Azoxystrobin + Tebuconazole @ 0.1% at the onset of disease development was found to be most effective, with 72.03% reduction observed over control. In conclusion, this study anticipates the use of Trichoderma asperellum and Pseudomonas fluorescens alongwith endophytes may be integrated for the successful management of kalmegh leaf spot disease. This recommendation only after testing at the farmer's field may be recommended for organic production of Kalmegh.