This study focuses on the valorization of a medicinal plant growing spontaneously in the El Bayadh region. It concerns Henophyton deserti coss & Durieu, known in Arabic as "henatl'ibel," used to treat various conditions such as intestinal disorders, lowering cholesterol levels and blood coagulation, as an antidiabetic, and for skin diseases. Organic extracts were obtained through hydrodistillation (methanolic, ethanolic, aqueous extracts). Phytochemical tests, thin-layer chromatography (TLC), and antioxidant activity of the methanolic extracts were conducted, along with microbiological activity tests for some extracts. Our results indicate that the plant is rich in flavonoids, tannins, phenols, starch, saponins, and sterols, while alkaloids, anthocyanins, and reducing compounds were absent. The DPPH assay showed an IC50 value of 3.69 mg/ml, indicating antioxidant activity. The antimicrobial activity results demonstrated sensitivity of the extracts against the bacterial strains used, including Staphylococcus and Listeria.