Drought stress is a serious stress leading to limited crop production in present climate changing era. The present investigation was carried out to evaluate the impact of sodium nitroprusside (nitric oxide donor) and brassinosteroid on mitigating drought stress responses in tomato plants. Experiment with two different water status was conducted with two tomato genotypes to study the mitigating effect of sodium nitroprusside (nitric oxide donor) and brassinosteroid. Drought stress was induced by withholding water for 7 days and normal irrigated plants were used as control. Nitric oxide donor, Sodium nitroprusside (SNP, 50 and 100 µ M) and 24-epibrassinolide (EBL, 1 and 3 µ M), applied singly and in combinations were used as foliar spray on the stressed plants. Drought stress produced various negative impacts in plants in terms of plant height, membrane stability index, malondialdehyde (MDA), proline content, flower drop percent, total soluble solids, polar fruit diameter and number of fruit plant-1. Exogenous foliar application of nitric oxide and brassinosteroid showed the extenuating effect under drought stress by increasing drought tolerance by overcoming negative effects of above mentioned morpho-physiological and biochemical attributes. Exogenous application of 100 µMSNP with 3 µM EBL showed significantly best results followed by 50 µM SNP plus 3 µM, EBL,50 µM SNP plus1 µM EBL and 100 µM SNP plus 1 µM EBL. Our results advocate that exogenous application of SNP and EBL application could significantly improve tolerance in tomato plants under drought stress by the significant changes in morpho-physiology and metabolic processes.