A field experiment conducted at Agricultural Research Farm, Division of Agronomy, BHU, Varanasi to evaluate the efficacy of herbicide to control of weeds in wheat crop. Weed flora of the experimental field was dominated by broad leaved weeds like Solanum nigrum, Anagallis arvensis, Chenopodium album, Vicia sativa, Melilotus indicus, Rumex dentatus, and Medicago denticulatum, narrow leaved weeds like Cynodon dactylon, Phalaris minor and sedges like Cyperus rotundus. In the experimental field weeds were controlled by pre-emergence application of herbicides viz.,pendimethalin 30% EC @ 600 g ha-1, pendimethalin 30% EC @ 900 g ha-1, pendimethalin 30% EC @ 1200 g ha-1, pendimethalin 30% EC @ 1500 g ha-1, metribuzin 70% WP @ 210 g ha-1and weed free (two hands weeding). All herbicidal treatment compare with Untreated Control (Weedy check). Among all herbicidal treatment pendimethalin 30% EC @ 1200 g ha-1 application is effective to control Phalaris minor, with WCE was 89.21%. Metribuzin 70% WP @ 210 g ha-1 have efficacy to control broad-leaf weed effectively and some narrow leaf weed. The highest grain yield observed in hand weeding (5693 kg ha-1) followed by herbicidal treatments, pendimethalin 30% EC @ 1200 g ha-1 (5078 kg ha-1). Highest B: C ratio (2.11) is achieved with the application of pendimethalin 30% EC @ 1200 g ha-1.