Studies conducted at Regional Research Station, Tamil Nadu Agricultural University, Vridhachalam, TamilNadu during rabi/summer 2016-17, 2017-18 and 2018-19 revealed the integration of herbicides with cultural method to contain weeds in groundnut under rice-groundnut system. Among the various herbicides tested, application of Pendimethalin 30% EC @ 1.50 kg a.i/ha followed by (fb) one hand weeding at 25 DAS recorded higher pod yield of 2443 kg/ha over rest of the herbicide combination treatments. The other treatments viz., pendimethalin 30% EC @ 1.5 kg a.i/ha fb Imazethpyr 10% S.L @ 75 g a.i/ha produced pod yield of 2212 kg/ha followed by pendimethalin 30% EC @ 1.50 kg a.i/ha fb quizalopfop ethyl 5 % E.C @ 50 g a.i/ha which gave 2171 kg/ha. All the treatment combinations were found on par with each other and significantly superior over control in terms of pod yield. The weed control efficiency was also higher (91 %) with application of pendimethalin 30% EC @ 1.50 kg a.i/ha fb one hand weeding at 25 DAS. The net return and benefit cost ratio was also higher with the same treatment i.e.application of pendimethalin 30% EC @ 1.50 kg a.i/ha fb one hand weeding at 25 DAS worked out with higher BCR (2.38).