Insecticide opposition and the adverse consequences of chemical pesticides on non-target organisms have propelled scientists to materialize alternative eco-friendly strategies. Entomopathogenic fungi are successfully devoted as an alternative to chemical spokespeople in supervising agricultural insect nuisances. It has an integral role in an endurable pest management program. With the advent of next-generation sequencing technologies, many fungal genes have been identified that are potentially useful for treating oral infections. Contaminating species from Lepidoptera, Hemiptera, Coleoptera, and Diptera are diasporic fungi genera such as Beauveria, Lecanicillium, Metarhizium, and Isaria species. Fungal spores can enter an insect's body through several natural openings, including its mouth, respiratory system, integumentary system, antennae, reproductive appendages, anus, glands open on the outside body wall, and wounds. Insect cuticles are a noteworthy barricade against fungal sickness, and internal defense mechanisms following entomopathogenic fungus invasion are poorly understood. Infestation usually occurs by growing an appressoria hyphen on the epicuticle and penetrating the hypodermis. Moreover, we depicted the mycotoxins of full potential in insect integrated governance, assuming all the factors exploiting their virulence and what conditions need to be met to make them more virulent against insects with some opposition to familiar illnesses. Mycotoxins should be integrated with nanotechnology and used as bioweapons for pest control in the future.