One of the top pest concerns in food production and storage across the globe, is stored product insects because they cause substantial damage and contamination. Insect infestations induce changes to the storage environment leading to warm, moist conditions which are suitable for fungal growth that further causes hazardous effects. The use of chemical insecticides to control pests can cause toxicity hazards to non-target organisms and serious health problems for humans. From this perspective, we assessed the effect of three botanical powders, Boswellia carterii (Sapindales Burseraceae), Elettaria cardamomum (Zingiberales: Zingiberaceae) and Pistacia lentiscus (Sapindales Anacardiaceae) against two stored-product pests, granary weevil Sitophilus granarius (Coleoptera Curculionidae) and confused flour beetle Tribolium confusum (Coleoptera Tenebrionidae). Both insects were affected by different powder concentrations, time of exposure, and the bioactivity of the plant components. Adult S. granarius were more sensitive to different powder concentrations than those of T. confusum. Concentrations of 15% B. carterii, E. cardamomum and P. lentiscus powders caused 73.3, 80, and 100% mortality of T. confusum after 14 days post treatment, respectively. While the same concentrations of the three botanical powders caused 100, 96.7, and 100% mortality of S. granarius. P. lentiscus was more effective than B. carterii and E. cardamomum. This study showed that B. carterii, E. cardamomum and P. lentiscus powders had biological and toxicological effects against S. granarius and T. confusum. These plant powders are considered safe for human use.