Field experiments were conducted during kharif and rabi season of 2013-14 and 2014-15 at at the Research Farm of Division of Agronomy, Main Campus, Chatha, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, to study the effect of tillage and weed management on plant growth, weeds dynamics, nutrient uptake, Microbial population and yield of maize-wheat cropping system under irrigated conditions. The experiments were laid out in strip plot design with three replications. Main plot treatment consisted of four tillage methods viz., Zero tillage followed by Zero tillage (ZT-ZT), Zero tillage followed by Conventional tillage (ZT-CT), Conventional tillage followed Zero tillage (CT-ZT) and Conventional tillage followed by Conventional tillage (CT). Three weed management methods viz., Hand weeding, pre-emergence application of herbicide (atrazine @ 1 kg/ha for maize and metribuzin @ 200g/ha for wheat) and Weeding Check for both the crops consisted as the sub plot treatments. The soil of the experiment field was sandy clay loam in texture. The result revealed that among various tillage and weed management practices conventional tillage fb conventional tillage (CT-CT) and atrazine @ 1 kg/ha in maize and conventional tillage fb conventional tillage (CT-CT) and Hand weeding for wheat were found effective as compared to other tillage and weed management treatments in increasing plant growth, nutrient uptake (NPK) and yield, and also reduced in weed density and weed biomass. Although microbial population were higher in Zero tillage followed by Zero tillage (ZT-ZT) and weedy check as compare to other treatments in maize-wheat cropping system.