The field experiment entitled “Effect of Irrigation Schedule and Fertigation Level on Nutrient Uptake and Soil Fertility of Mandarin (Citrus reticulate Blanco.) cv. Nagpur Mandarin" was conducted by deploying 10 treatments in RBD with four replication covering 160 plants in all during two successive years commencing from March 2019 to February 2021 at the Instructional Farm, Department of Fruit Science, College of Horticulture and Forestry, Jhalawar, Rajasthan. The experiment revealed that among various irrigation schedule treatments, the application of treatment I1 (100% ETc) was observed significantly superior over other treatments concerning leaf parameters in which the increase in leaf NPK content particularly N: 2.53%, P: 0.23%, K: 1.72% and soil NPK particularly N: 319.13 kg ha-1, P:24.58 kg ha-1, K: 290.92 kg ha-1 at 0-15cm depth were observed under this treatment I1 (100% ETc). As regard to individual effect of fertigation, maximum leaf NPK content (N: 2.56% P: 0.23%, K: 1.75%) and soil NPK particularly N: 322.28 kg ha-1, P: 26.10 kg ha-1, K: 295.25 kg ha-1 at 0-15cm depth were observed under the treatment F1 (100% RDF). Among the interaction of irrigation schedule and fertigation levels, leaf and soil parameters were observed significantly superior in treatment I1F1 (Irrigation Scheduling at 100 % ETc + Fertigation 100 % RDF) while treatment I2F1 (Irrigation Scheduling at 80 % ETc + Fertigation 100 % RDF) was registered followed by with it in most of the leaf parameters and soil parameters was observed at par with treatment I2F1 studied.