A major constraint in the production of potato tubers is its vulnerability to various soil borne, air borne and tuber-borne diseases, including late blight (Phytophthora infestans), early blight (Alternaria solani), wart disease of potato (Synchytrium endobioticum), common scab (Streptomyces scabies), powdery scab (Spongospora subterranea), dry rot (Fusarium spp.), Sclerotium wilt (Sclerotium rolfsii), Verticillium wilt (Verticillium alboatrum) and black scurf (Rhizoctonia solani). Among these, black scurf induced by Rhizoctonia solani is prevalent throughout the state, resulting in significant yield losses. Induction of resistance in potato against black scurf disease was studied by treating the highly susceptible potato tuber to black scurf disease using the defense activator salicylic acid, hydrogen peroxide (H2O2), Boric acid and calcium chloride (CaCl2) each @0.25 g per litre were efficient in managing the disease incidence by giving 59.54 and 60.18% protection from disease incidence and 78.96 and 78.16% reduction in disease index respectively, against black scurf disease. Optimization of time gap between the spray of inducer and inoculation with Rhizoctonia pathogen identified gap of 11 days for building of maximum resistance. Inducer treatment not only offered crop protection against but also increased the vegetative and reproductive growth parameters and enhances the yield of tubers. Among the inducers used, salicylic acid provide more protection than boric acid, calcium chloride and hydrogen peroxide but boric acid and salicylic acid are statistically at par with each other. Crop raised from salicylic acid and calcium chloride showed more pronounced vegetative and reproductive growth parameter as compared to other inducer.