A field study was conducted to evaluate the effects of biofertilizer consortia (BF), natural farming components (NF), and their combined application (BF+NF) on soil chemical properties, nutrient dynamics, microbial activity, and maize production. The results revealed that integrated application of BF+NF significantly improved soil health and crop performance compared with individual treatments and the control. Soil organic carbon increased markedly under BF+NF, reaching 0.82%, representing a 5.13% increase over the control, while soil pH remained statistically unchanged. The highest available nitrogen (241.89 kg ha⁻¹), phosphorus, and potassium (285 kg ha⁻¹) contents were recorded under BF+NF treatment. Soil DTPA-extractable Zn was also significantly enhanced, with the maximum value of 5.13 mg kg⁻¹ observed under BF+NF. Nutrient uptake by maize was significantly improved, with the highest nitrogen, phosphorus, and potassium uptake recorded in both cobs and stover under integrated application. Maize cob and stover yields were significantly greater in BF+NF plots, followed by NF and BF treatments. Enzymatic activities, including dehydrogenase, β-glucosidase, acid phosphomonoesterase, and aryl sulphatase, increased significantly under BF+NF, indicating enhanced biological functioning of soil. Acid phosphomonoesterase activity increased by 53.14% over the control. Microbial biomass carbon, nitrogen, and phosphorus were also highest under BF+NF, with microbial biomass phosphorus showing a 63.35% increase compared to the control. The study demonstrates that combined application of biofertilizer consortia and natural farming components effectively enhances soil fertility, microbial activity, nutrient uptake, and maize productivity, supporting sustainable crop production.