The combination of organic manures and fertilizers played a crucial role in improvement of soil physico-chemical properties, transformation and distribution of macro and micro-nutrients under various cropping system. The non-availability of good quality water for irrigation especially in arid and semi-arid regions of Haryana led to development of soil salinity that interferes with sustainable crop production. The study was conducted with the aim to explore the appropriate combination of manures and fertilizers under such conditions in pearl millet-wheat cropping system on sandy loam soils of Haryana (India). The use of organic manures along with fertilizers and bio-fertilizers resulted in improved nutrient status of soil enhancing both micro and macro nutrient pools in soil. The combination of fertilizers with organic manures reduced the soil pH up to greater extent over sole application of inorganic fertilizers under salt stress conditions. The INM reduced the bulk density, increased the water holding capacity and improved the overall soil health. This resulted in increased transformation of micro and macro nutrients in soil, thus enhancing their uptake by plants giving higher crop production.