The present study is conducted to gather the native awareness of therapeutic plants of Lodhran District, south Punjab, Pakistan, and documentation of remarkable wild plants. The area hasten been studied before for his purpose. The area is rich in medicinal plans and local people are using I for various ailments. This study was donein 2019. The information was collected through specific questionnaires and field trips and local health care professionals including Hakeems, Daii, and Peer (Spiritual Healers) were interviewed. Documented plants were further identified by Flora of Pakistan. An overall of 66therapeutic plants with 36 families was acknowledged through various field trips and with detailed interviews of the specific people in the community and their local names and folk uses are described along with their dosage forms.