A field experiment was carried out during Kharif (July to October) season of 2017 and 2018 at CCSHAU Regional Research Station, Bawal, India to enhance the productivity and profitability of pearl millet through mechanized interculture, suitable crop geometry and agro-chemicals under rainfed conditions of south-western Haryana, India. The crop was infested with Nutsedge (Cyperus rotundus), Carpet weed (Trianthema portulacustrum), Phyllanthus niruri, Barn yard grass (Echinochloa colona), Digera arvensis) and Crow root grass (Dactyloctenium aegyptium) etc. Two mechanized interculture with tractor drawn cultivator 15 and 25 DAS under crop geometry of 60cm ×10cm with seed priming with thiourea 500 ppm solution for 30 minutes before sowing and foliar spray of 0.5% NPK at tillering was found more remunerative with grain yield of 2.77 and 1.93t/ha, and 32 and 74; and 43 and 171 % higher net returns, and B:C ratio of 1.79 and 1.49 compared to the recommended manual interculture operation with wheel hand hoe or kasola at 20-25 and 30-35 DAS under 45cm x 12cm crop geometry during 2017 and 2018, respectively. Mechanized interculture with tractor drawn cultivator twice at 15 and 25 DAS under crop geometry of 60cm ×10cm without seed priming with thiourea and foliar spray of NPK was the second best treatment in terms of B:C during both years viz. 1.68 and 1.45 during 2017 and 2018, respectively.These two treatments also provided efficient control of weed (76 - 88%), however, the WCE (89 - 93%) was bit higher under recommended two interculture operations with Kasola or wheel hand hoe.Weeds allowed to grow throughout the crop season caused yield loss in pearl millet to the extent of 33.7 and 35.1% during 2017 and 2018, respectively.