A field experiment was carried out at Agricultural Research Station, Kota (Rajasthan) during rabi-2017-18 & 2018-19 to evaluated efficacy of sulfoxaflor 12% SC against aphids viz., aphids (Myzus persicae). The various doses of sulfoxaflor 12% SC i.e. 175, 200, 225 and 450 ml/ ha (450 ml/ha only for phytotoxicity test) along with standard check thiamethoxam 25 % WG at 100 g/ha were evaluated against aphids of potato. The minimum population (0.95 & 0.75 and 1.46 & 0.96 aphids/plant) was recorded in sulfoxaflor 12% SC @ 225 ml/ha after 10 days of spray during 2017-18 & 2018-19, respectively and was statistically significant in compare to other treatments. It was followed by sulfoxaflor 12% SC @ 200 ml/ha and thiamethoxam 25% WG @ 100 g/ha. The highest mean tuber yield of 10.69 t/ha was recorded in sulfoxaflor 12% SC @ 225 ml/ha followed by sulfoxaflor 12% SC @ 200 ml/ha. The different doses of sulfoxaflor 12% SC i.e. 225 and 450 ml/ ha did not cause any phytotoxicity symptoms to potato crop besides this all treatments of insecticides not differ significantly population of natural enemies during study period.