A field experiment entitled “Effect of Weed Management Practices on weed control efficiency, yield and economics of transplanted rice was conducted during Kharif 2016 at Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut, U. P. (India) to find out the impact of different herbicides on weed flora, yield and economics of transplanted Rice (Oryza sativa L.). Among weed management practices sole application of Pyrazosulfuron fb Bispyribac Sodium (150 g a.i ha-1 PE fb 25g a.i ha-1 POE), Pyrazosulfuron (150 g a.i ha-1 PE), Butachlor (1.5 kg a.i ha-1) obtained selectivity towards broad leave weeds, whereas Oxidiargyl (100 g a.i ha-1 PE), Anilophos fb Bispyribac Sodium (400 g a.i ha-1 PE fb 25g a.i ha-1 POE), Pyrazosulfuron fb Bispyribac Sodium (150 g a.i ha-1 PE fb 25g a.i ha-1 POE) performed selectivity towards narrow leave weeds, respectively. Similarly, Pyrazosulfuron fb Azimsulfuron (150 g a.i ha-1PE fb 30 g a.i ha-1 POE) recorded selectivity towards narrow leave weeds. Among weed management practices, this research finding indicates that the application of Pyrazosulfuron fb Bispyribac Sodium (150 g a.i ha-1 PE fb 25g a.i ha-1 POE) proved to be the most effective in minimizing the total weed density (5.0,6.26 and 6.10 m-2), biomass of weed and enhancing the weed control efficiency (74.96 %), grain yield (46.20), net return (47902) and benefit ratio (2.27) which have the potential of being used as best combination of herbicides. Effective weed control practices could be used for the better production of transplanted rice in Typic Ustochrept soil of Uttar Pradesh.