Melia azedarach belongs to family Meliaceae. It is a deciduous tree, native to Indian sub-continent but now has spread in many Asian countries and also in different regions of the globe. It is an economically and medicinally important woody tree that is traditionally used for management of malaria, diabetes and skin diseases. It is highly valuable indigenous species. The main difficulty of establishing forest plantation of Melia azedarach species is its poor seed germination. Seed of Melia azedarach are hard and seed pre-treatments aim at breaking the physical barrier to enhance water absorption. The experiment consisted of 38 treatments in which various pre-sowing treatments were applied to the drupes such as normal water (24, 48 and 72 hrs), hot water (4, 6 and 8 min.), hot water with keeping drupe in same water for 24 hrs (4,6 and 8 min.), conc. H2SO4 (4, 6 and 8 min.), Gibberellic acid (200, 300 and 400 ppm for 24 hrs), cow dung slurry (2, 4 and 6 days) and these treatments were also given in combination with mycorrhizal fungi namely Glomus mosseae. Results revealed that the germination, growth, biomass and physiological parameters of pre-sowing treated drupes were significantly increased as compared to control, except for hot water treatment. The germination percentage (75.87) and other quality parameters such as mean daily germination, germination value and speed of germination were recorded highest in treatment with cow dung slurry for 6 days + Glomus mosseae followed by cow dung slurry for 6 days.