The present investigation in titled “Effect of growth regulators and vermicompost on female flower in bottle gourd [Langeraria sicenaria (mol.) standl.]’’ by Growth Regulators” at the Horticulture Research Farm, R.A.K college of Agriculture, Sehore (M.P.) during 2019-20 and 2020-21. This experiment was laid down in Randomized block design with three replications. The thirteen treatments viz., T1 (GA3 0 ppm + Vermicompost @ 0), T2 (GA3 25 ppm + Vermicompost. @ 2 t/ha), T3 (GA3 50 ppm + Vermicompost @ 4 t/ha), T4 (GA3 75 ppm + Vermicompost @ 6 t/ha) T5 (Etherel 100 ppm + Vermicompost @ 2 t/ha.), T6 (Etherel 200 ppm + Vermicompost @ 4 t/ha.), T7 (Etherel 300 ppm + Vermicompost @ 6 t/ha.) T8 (NAA 100 ppm + Vermicompost@ 2 t/ha.), T9 (NAA 150 ppm + Vermicompost @ 4 t/ha.), T10 (NAA 200 ppm + Vermicompost @ 6 t/ha.), T11 (CCC 200 ppm+ Vermicompost @ 2 t/ha.), T12 (CCC 400 ppm + Vermicompost @ 4 t/ha.) and T13 (CCC 600 ppm + Vermicompost @ 6 t/ha.) were evaluated during the experiment. The maximum days taken to first female flower were recorded under the treatment T1 (61.33 in 2019-20) and (62.00 in 2020-21). While the minimum days taken to first fruit picking significantly recorded under the treatment T6. In relation to sex ratio, the maximum sex ratio of flowers recorded under the treatment T1 (11.67 in 2019-20) and (10.83 in 2020-21. While the minimum sex ratio of flowers v experiment the treatment T6 found superior compare to control treatment.