A field experiment was conducted during kharif season of 2014 at Sher-e- Kashmir University of Agricultural Sciences and Technology, research farm of division of agronomy Jammu to study the effect of different varieties and fertility levels on growth, yield, quality and nutrient uptake of hybrid rice cultivars under sub-tropical irrigated conditions. The experiment was laid out in Factorial Randomized Block Design with 16 treatments combinations and three replications. The treatments consisted of four varieties varieties V1 (PRH-10), V2 (DRRH-3), V3 (Indra Sona) and V4 (PHB-71) as one factor and four fertility levels F1 (N60:P30:K15 kg/ha); F2 (N90:P45:K23 kg/ha); F3 (N120:P60:K30 kg/ha) and F4 (N150:P75:K38 kg/ha) as second factor. Among hybrids, PHB-71 recorded significantly higher plant height, dry matter accumulation, number of panicles/m2, number of grains/panicle, 1000-grain weight, grain yield and straw yield. Application of N120:P60:K30 kg/ha and N150:P75:K38 kg/ha produced significantly higher plant height, dry matter accumulation, number of panicles/m2, number of grains/panicle, 1000-grain weight, grain yield and straw yield than N60:P30:K15 kg/ha and N90P45K23 kg/ha. The variety DRRH-3 recorded significantly higher protein content (8.57%) followed by PHB-71 and (PRH-10). However, being non-significant the variety DRRH-3 and fertility level F3 (N120P60K30 kg/ha) recorded highest starch content of (72.26%) and (72.76%) respectively. The variety PHB-71 has significantly higher nutrient uptake both in grain and straw followed by the variety DRRH-3, Indra Sona and PRH-10. The increase in nutrient uptake with F3 (N120P60K30 kg/ha) and F4 (N150P75K38 kg/ha) levels found to be superior over F1 (N60P30K15 kg/ha) and F2 (N90P45K23 kg/ha). The highest net returns (Rs 83514) and benefit: cost ratio (2.59) was recorded with PHB-71 followed by DRRH-3 (2.19). However, the highest net returns (Rs 78379) was obtained with N150P75K38 kg/ha followed by N120P60K30 kg/ha level whereas the B:C ratio (2.36) was higher in N120P60K30 kg/ha.