Wheat (Triticum aestivum L.) is the staple food of 40 percent human population across the globe and requires adequate supply of nutrients especially nitrogen for its growth and yield. Therefore, an investigation entitled “Effect of nutrient management in wheat for improving fertilizer use efficiency, productivity and soil health” was conducted to sustain and enhance the productivity and soil health through novel sources of nutrients and their mode of applications on wheat variety DBW 71 with 14 treatments consisting of control, basal applications of recommended NPK(80:60:40)/NPK Granules (200 kg ha-1) + FYM (5 t ha-1) + Bio-stimulant granules ( 62.5 kg ha-1) +NPK Bio-fertilizer(seed treatment) and top dressing of urea 20 (kg ha-1)/ bio-stimulant(625ml/ha)/ NPK Powder (1%) sprays (40/55/70 DAS) in various combinations in RBD with 3 replications at crop research centre of SVPUA&T, Meerut (U.P.) during rabi 2017-19.The soil was well drained sandy loam, low in organic carbon and available nitrogen, medium in available phosphorus and potassium with slightly alkaline pH. The results of the study revealed that wheat when grown with incorporation of FYM +Bio-stimulant –L attainted significantly better growth as reflected by higher plant population, taller plants, higher LAI, LAD CGR,RGR,NAR, and higher dry matter accumulation across the stages. Application of FYM@ 5t/ha+NPK-G@200kg/ha + NPK-bio-fertilizer + Urea @ 20kg/ha and foliar spray of NPK-P @ 1% along with bio-stimulant-L@ 625 ml/ha (T-14) resulted in maximum accumulation of dry matter @ 151g/m1 at harvest in comparison to recommended NPK, while it remained at par with nutrient management practice involving application of FYM@ 5t/ha+NPK-G@200kg/ha + NPK-bio-fertilizer and foliar spray of NPK-P @ 1% along with bio-stimulant-L@ 625 ml/ha (T-13) and FYM @5t/ha +NPK 200kg/ha + NPK-bio-fertilizer + Urea@ 20 kg/ha each as basal &40 DAS + Bio-stimulant-L @ 625ml/ha (T-12) upto 90 DAS and at harvest stages. Thus, the wheat crop grown with application of FYM@ 5t/ha+NPK-G@200kg/ha + NPK-bio-fertilizer + Urea @ 20kg/ha and foliar spray of NPK-P @ 1% along with bio-stimulant-L@ 625 ml/ha had attained better growth (plant height, dry matter accumulation, LAI,LAD,CGR,RGR and NAR. Significantly improved the protein content and protein yield.