Charcoal rot incited by Macrophomina phaseolina is an economically important disease of sesame. Sesame is one of the important oilseed crops and high valued due to nutritional and medicinal properties. Weather variables predisposed M. Phaseolina for quantification of disease progression at different rate and differential reaction on sesame varieties. Differential reaction of M. phaseolina on sesame varieties was studied during three different dates of sowing. Progression of disease was found highest during period of 18th August and 23rd August in all dates of sowing. Maximum disease incidence was recorded in early sown crop followed by mid and late sown conditions. Higher charcoal rot disease incidence was recorded in variety HT1 than HT2 during different dates of sowing. The progression of charcoal rot disease over a time was assessed by area under disease progress curve. Area under disease progress was recorded higher in variety HT1 than HT2 in all three different dates of sowing. It was observed maximum during early date of sowing followed by mid and late sown conditions.