The IDM practices have ability to increase growth parameters, yield and soluble protein and total phenol content and on the other hand decreases disease severity of late blight of potato. The highest plant height was found in T9 (Soil application of FYM + Poultry manure + Tuber treatment with T. harzianum+ three foliar spray with Equation Pro) treated plant representing the value 6.15 and 34.05 cm during 2016-17 and 6.30 and 34.65 cm during 2017-18 at 15 and 45 days age of seedling. Similarly, total yield as 417.30 and 449.40 gm per plant was also obtained from T9 (Soil application of FYM + Poultry manure + Tuber treatment with T. harzianum + three foliar spray with Equation Pro) treated plant, against 218.78 gm and 211.68 gm in case of control in year 2016-17 and 2017-18 respectively. The minimum disease severity of late blight of potato as 1.65 and 5.28% during 2016-17 and 1.70% and 5.35% during 2017-18 were recorded in T9 (Soil application of FYM + Poultry manure + Tuber treatment with T. harzianum + three foliar spray with Equation Pro) treated plant as against 30.12% and 48.84% (2016-17) and 30.50 and 49.05 % in case control at 45 and 60 days, respectively. Biochemical analysis of treated plants was also observed due to adaptation of IDM practices that soluble protein content in potato leaves due to IDM approaches ranges from 16.55-23.75 mg/g of fresh leaves with maximum in T9 treated potato leaves, indicating 34.02, 35.32, 36.54 and 37.97 mg/g of fresh leaves at 2, 4, 6 and 8 days of pathogen inoculation during 2016-17. Similar trend of observation has also been found during 2017-18. Similarly, the total phenol content as compared to control at 2, 4, 6 and 8 days of pathogen inoculation was also found in T9 (Soil application of FYM + Poultry Manure + Tuber treatment with T. harzianum + three foliar spray with Equation Pro) treated potato leaves posses increased percent of total soluble phenol as 81.91 % over control at 8 days of pathogen inoculation. Similarly, during 2017-18, the maximum total phenol content was also found in T9 treated potato leaves which were 2.69 mg/g, 3.21 mg/g, 3.31 mg/g and 3.40 mg/g of fresh leaves at 2, 4, 6 and 8 days of pathogen inoculation.