Cassava wastewater contain high organic load (suspended solids(SS); Chemical Oxygen Demand(COD), turbidity, odor, and cyanide(CN). Cassava processing factory discharge this effluent into water bodies without treatment. The objective of this work is to develop a multistage Cassava Waste Treatment System (CWTS) using acrylic glass (Perspex) material with suitable flow kinetics for cassava effluent decontamination. Each of the columns contained up to 4 mm of 6mm milled chicken feathers and cotton wool as filter media. Control valves A-E maintained flow rates at 0.000508 (A) and 0.002 liters/second (B, C, D) during testing. Dimensions of the treatment column were: column 1: 400 mm x 160 mm x 160 mm: column 2: 300 mm x160 mm x 160 mm, column 3: 270 mm x 160 mm x 160 mm and column 4: 200 mm x 160 mm x 160 mm. 4 cups were inserted cups as the base of filter beds each containing a 3mm drilled hole for the passage of the treated effluent. Cups: 1 and 3 were filled with milled chicken feather while 2 and 4 cotton wool. When tap A was opened, 2-litre of the effluent was released onto column 1 for treatment during this period, taps B, C, D, and E were closed. For 10-20 minutes, the control tap B was opened while taps A, D, C, E were closed as further treatment occurred in column 2. Removal efficiency of the CWTS were 60-80% for SS,65-70% odor, 60-72% COD, and 80-90% turbidity level and cyanide 40 to 50%.