A field experiment was conducted during Rabi season 2019-2020 and 2020-2021 at Research farm, Indira Gandhi Agricultural University, Raipur (Chhattisgarh) in order to study the soil test based fertilizer recommendation for safflower crop on the basis of grain yield, nutrient uptake, and initial soil test data which were used forgenerating basic parameters, such as nutrient requirement, contribution of nutrients from soil, fertilizer, and organic manure. It was discovered that for a safflower crop to yield one quintal of grain, 3.99 kg of N, 0.94 kilogram of P, and 6.43 kg of K were needed.The fertilizer and soil test efficiencies for N, P, and K were 28.41, 18.33, and 138.70 percent as well as 15.75, 51.59, and 11.13 percent, respectively. For N, P, and K efficiency of FYM was calculated as 10.08, 5.21, and 8.12 percent, respectively. These factors were used to generate STCR based fertilizer prescription equations along with ready reckoners of fertilizer using FYM as the organic component of the INM technique for N, P2O5 and K2O at different soil fertility levels and yield targets of safflower for providing balanced fertilization.