Brinjal (Solanum melongena) belongs to the family Solanaceae, it is an important vegetable crop and grown all around the world. It is one of the most important hosts for plant parasitic nematodes, mainly root-knot nematode, Meloidogyne javanica. Experiments were conducted to test the efficacy of oil-cakes (viz., castor, mahua, karanj, mustard and neem cake) against root-knot nematode in laboratory condition (per cent hatching and per cent mortality after 24, 48 and 72 hours) through different concentration (0.5, 1, 2, 5 and 10 per cent), management of root- knot nematode in brinjal (@ 10 per cent) in pot and field condition and tested the effect of oil-cakes on estimation of PPO, PAL and Phenol in brinjal roots. Results showed that all the tested oil-cakes significantly reduced the per cent hatched juveniles and increased the per cent mortality of juveniles, increased the brinjal plant growth parameter as well as reduced nematode reproduction and increased the level of PPO, PAL, and phenol in brinjal roots as compared to untreated check. Among the tested oil-cakes neem cake was found most effective treatment with minimum per cent hatched juveniles and maximum per cent mortality of juveniles @ 10 per cent concentration after 72 hrs. Similarly, neem cake @ 10 per cent concentration was found superior to improving plant growth parameters, reducing nematode population and to enhance PPO, PAL, and phenol activity.