In Cauvery Delta Zone (CDZ) of Tamil Nadu, Sugarcane is an important commercial crop with wider spacing and lond duration which suffers from weeds where weed management studies are vey meagre. Therefore, the present experiment was conducted during the special season of 2016-17 to 2018-19 at Sugarcane Research Station, Sirugamani, Tamil Nadu to evolve suitable weed management practices for weed control in Sugarcane in the CDZ for increasing the cane yield. The experiment was laid out in RBD replicated thrice with 8 treatments using TNAU Sugarcane Si8 as test variety. The treatments consisted of pre emergence herbicides in combination with post emergence herbicides or weeding by power tiller or intercropping with daincha. The crop yield parameters, weed control efficiency and economics were observed. Significantly higher cane yield (123.3 t/ha), highest net income (Rs. 2,11,220/ha) and BCR (3.02) along with highest weed control efficiency (50.4%) at 240th day was recorded with application of Pre-emergence herbicide (atrazine @1.00 kg/ha) and post emergence herbicide (Metribuzin @ 0.75 kg/ha) at 60 days after planting.