This comprehensive study delves into the intricate dynamics of three Integrated Farming System (IFS) models implemented in the Ri-Bhoi District of Meghalaya, India, focusing on Marngar and Sarikhusi villager clusters under the Farmers' First Programme (FFP). Spanning the years 2017 to 2023, these models, designated as IFS I, IFS II, and IFS III, integrate various agricultural enterprises, including fishery, poultry, piggery, dairy, crops, goatery, and mushroom farming. The results reveal a remarkable transformation in the economic landscape for small and marginal farmers adopting these IFS models. In the case of IFS I, covering a 2.47-acre farm, the annual gross income surged from Rs. 1.73 lakhs to an impressive Rs. 6.23 lakhs post-intervention. IFS II, operating on a 1.4-acre farm, showcased the effectiveness of integrating diverse enterprises. The model, incorporating piggery, fishery, poultry, duckery, crops, goatery, and mushroom farming, demonstrated a commendable average annual gross income of Rs. 3.60 lakhs. In the case of IFS III, which encompassed crops, fishery, poultry, and piggery on a 1.10-acre farm, the results indicated an almost twofold increase in annual gross income compared to the baseline. The benefit-cost ratio for IFS III was calculated at 2.38, affirming its profitability. The implications of these findings extend beyond the specific regions studied. Policymakers and agricultural extension services can leverage these insights to design and implement similar interventions in diverse agro-ecological contexts, aiming to promote sustainable agricultural practices. The success of these IFS models suggests a scalable and replicable approach that could contribute to holistic agricultural development and poverty alleviation in various rural settings.