Vitamin and mineral injections can increase cellular nutrition availability, which is essential for lowering transition period stress and improving dairy cow health and productivity. The purpose of this study was to assess the colostrum quality and the health of the calf after intramuscular injection of multi-mineral and multi-vitamins to peripartum cows throughout the months of winter. For every season, twenty-four pregnant crossbred Karan Fries cows were grouped into four groups, each with six cows. In the control group i.e. Group 1 was given only a basal diet and no extra treatments. Multivitamin injections were given to group 2, multimineral injections to group 3, and a combination of multivitamin and multimineral injections to group 4. Blood samples were taken one, three, seven, fifteen, and twenty days prior to parturition, as well as the same number of days following it. The group receiving multimineral injections had lower cortisol levels than the group receiving multivitamin injections, while the group receiving simply basel diet had the highest cortisol levels (P<0.05). IGF1 levels were lowest in the group given only basal diet, followed by multivitamin and multimineral injections, and highest in the group that received a combination of multivitamin and multimineral injections.