Chilli leaf curl disease has emerged as a significant threat to chilli production in South India, particularly in major growing regions. To effectively manage this disease, understanding its spatial distribution and infection risk is crucial. A temperature-based infection model was developed for precise risk assessment, quantified as the monthly cumulative value of the daily infection index. Leveraging 39 years of historical weather data and 2 years of on-ground surveys (2021-2022), a geospatial analysis of infection risk was conducted. The study highlighted elevated risk during the kharif season, identifying Karnataka, Telangana, and parts of Kerala as prominent hotspots. Year-to-year variations underscored the vulnerability of chilli cultivation to climate change-induced temperature increases. This predictive approach, rooted in critical weather factors, holds implications for germplasm conservation, pesticide evaluation, and management strategy development. Overall, this research enhances our capacity to proactively mitigate the impacts of chilli leaf curl disease on agricultural productivity.