Salvia argentea L., commonly called silver sage, a species belonging to the Lamiaceae family and commonly known as «Ferrache en neda» in Algeria, has a significant presence in traditional medicine. This study was devoted to explore the contents of total polyphenols, flavonoids, and tannins in the hydro-methanolic extract of Salvia argentea L. aerial part and assessing its antioxidant, and anti-inflammatory properties. The colorimetric methods; Folin-Ciocalteu, Aluminium trichloride and vanillin were used for the estimation of polyphenols, flavonoids and condensed tannins, respectively. The DPPH radical scavenging and total antioxidant capacity (TAC) assays were used to estimate antioxidant activity. The anti-inflammatory potential was tested in mice models of ear edema induced by Croton oil and xylene. The results showed an extraction yield of 6.03%. The phytochemical analysis demonstrated the extract's abundance in polyphenols with a ratio of 75.56±0.56 (mg GAE/gE) and subsequently with tannins (36.93±1.74 mg CE/gE), and a moderate ratio of flavonoids (16.44±0.17 mg QE/gE). The antioxidant results confirmed that SACrE exhibited a strong activity against the DPPH radical (IC50: 0,085±0,0002 ± mg/mL) compared with BHT, as well as an effective phosphomolybdenum reducer power (EC50: 0,147±0,005 mg/mL). In the anti-inflammatory test, oral administration of SACrE with its three different doses (200, 400, and 600 mg/kg) significantly reduced edema in both models. At a dose of 600 mg/kg, the extract showed substantial inhibition, reaching 58,78 % against xylene-induced ear edema. On the other hand, in croton oil-induced edema, the extract showed notable inhibition of ear edema, displaying a reduction of 81.33% using 400 mg/kg of extract. This study highlighted SACrE's antioxidant, and anti-inflammatory capacities. They also underlined the crucial role of S. argentea L., as a reservoir of potentially beneficial compounds for therapeutic applications.