The aim of the study was to assess the antibacterial activity and phytochemical properties of leaf extracts of two common weed plants Ghamra and Apamarga. Aqueous and methanolic extracts were prepared using maceration and soxhlet extraction method. The extraction solvent was selected on qualitative analysis of antibacterial activity. Antibacterial potency of leaf extracts was tested by agar well diffusion method at different concentrations (10, 15 and 20 mg/ml) against two common human pathogens gram positive bacteria Bacillus cereus and gram-negative bacteria Pseudomonas aeruginosa. The results revealed that aqueous extract of Ghamra and methanolic extract of Apamarga were more effective. It was also found that Ghamra and Apamarga leaf extracts showed maximum zone of inhibition at 20 mg/ml concentration i.e. 20 mm and 18 mm against Bacillus cereus and 17.8 mm and 16.5 mm against Pseudomonas aeruginosa.